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ADAMTS17-NCF4 Gene Fusion FISH Probe

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Catalog: GFFP-ADAMTS17/NCF4-00060
Classification: Gene Fusion FISH Probes
Description: The ADAMTS17-NCF4 Gene Fusion FISH Probe can detect the fusion of ADAMTS17 and NCF4 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: ADAMTS17-NCF4 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Neutrophil Cytosolic Factor 4
Gene Summary 1 The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 22
Locus 1 22q12.3
Coordinates 1 This gene maps to 37257029-37274059 in GRCh37 coordinates.
Gene Name 2 ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17
Gene Summary 2 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Chromosome 2 Chromosome15
Locus 2 15q26.3
Coordinates 2 This gene maps to 100511642-100882183 in GRCh37 coordinates.
Associated Diseases Skin Cutaneous Melanoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-ADAMTS17/NCF4-00060-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-ADAMTS17/NCF4-00060-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-ADAMTS17/NCF4-00060-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-ADAMTS17/NCF4-00060-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-ADAMTS17/NCF4-00060-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-ADAMTS17/NCF4-00060-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-ADAMTS17/NCF4-00060-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-ADAMTS17/NCF4-00060-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-ADAMTS17/NCF4-00060-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-ADAMTS17/NCF4-00060-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-ADAMTS17/NCF4-00060-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-ADAMTS17/NCF4-00060-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-ADAMTS17/NCF4-00060-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-ADAMTS17/NCF4-00060-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-ADAMTS17/NCF4-00060-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-ADAMTS17/NCF4-00060-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-ADAMTS17/NCF4-00060-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-ADAMTS17/NCF4-00060-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-ADAMTS17/NCF4-00060-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-ADAMTS17/NCF4-00060-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-ADAMTS17/NCF4-00060-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-ADAMTS17/NCF4-00060-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-ADAMTS17/NCF4-00060-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-ADAMTS17/NCF4-00060-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-ADAMTS17/NCF4-00060-AQAQ 467nm;467nm 418nm;418nm

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