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ZNF292-MAP3K4 Gene Fusion FISH Probe

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Catalog: GFFP-ZNF292/MAP3K4-13630
Classification: Gene Fusion FISH Probes
Description: The ZNF292-MAP3K4 Gene Fusion FISH Probecan detect the fusion of ZNF292 and MAP3K4 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: ZNF292-MAP3K4 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Mitogen-activated Protein Kinase Kinase Kinase 4
Gene Summary 1 The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
Chromosome 1 Chromosome 6
Locus 1 6q26
Coordinates 1 This gene maps to 161412821-161538417 in GRCh37 coordinates.
Gene Name 2 Zinc Finger Protein 292
Gene Summary 2 This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]
Chromosome 2 Chromosome6
Locus 2 6q14.3
Coordinates 2 This gene maps to 87865268-87973406 in GRCh37 coordinates.
Associated Diseases Sarcoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-ZNF292/MAP3K4-13630-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-ZNF292/MAP3K4-13630-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-ZNF292/MAP3K4-13630-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-ZNF292/MAP3K4-13630-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-ZNF292/MAP3K4-13630-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-ZNF292/MAP3K4-13630-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-ZNF292/MAP3K4-13630-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-ZNF292/MAP3K4-13630-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-ZNF292/MAP3K4-13630-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-ZNF292/MAP3K4-13630-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-ZNF292/MAP3K4-13630-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-ZNF292/MAP3K4-13630-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-ZNF292/MAP3K4-13630-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-ZNF292/MAP3K4-13630-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-ZNF292/MAP3K4-13630-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-ZNF292/MAP3K4-13630-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-ZNF292/MAP3K4-13630-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-ZNF292/MAP3K4-13630-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-ZNF292/MAP3K4-13630-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-ZNF292/MAP3K4-13630-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-ZNF292/MAP3K4-13630-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-ZNF292/MAP3K4-13630-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-ZNF292/MAP3K4-13630-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-ZNF292/MAP3K4-13630-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-ZNF292/MAP3K4-13630-AQAQ 467nm;467nm 418nm;418nm

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