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UVRAG-LRTOMT Gene Fusion FISH Probe

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Catalog: GFFP-UVRAG/LRTOMT-12902
Classification: Gene Fusion FISH Probes
Description: The UVRAG-LRTOMT Gene Fusion FISH Probecan detect the fusion of UVRAG and LRTOMT genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: UVRAG-LRTOMT Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 UV Radiation Resistance Associated
Gene Summary 1 This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 11
Locus 1 11q13.5
Coordinates 1 This gene maps to 75526211-75855282 in GRCh37 coordinates.
Gene Name 2 Leucine Rich Transmembrane And O-methyltransferase Domain Containing
Gene Summary 2 This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein. There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2. LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51, while LRTOMT2 shares similarity with the protein encoded by mouse Tomt. Alternative splicing results in multiple transcript variants, encoding different isoforms of both LRTOMT1 and LRTOMT2. The LRTOMT1 protein is a leucine-rich repeat-containing protein, while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. [provided by RefSeq, Nov 2017]
Chromosome 2 Chromosome11
Locus 2 11q13.4
Coordinates 2 This gene maps to 71791376-71821828 in GRCh37 coordinates.
Associated Diseases Breast Invasive Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-UVRAG/LRTOMT-12902-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-UVRAG/LRTOMT-12902-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-UVRAG/LRTOMT-12902-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-UVRAG/LRTOMT-12902-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-UVRAG/LRTOMT-12902-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-UVRAG/LRTOMT-12902-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-UVRAG/LRTOMT-12902-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-UVRAG/LRTOMT-12902-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-UVRAG/LRTOMT-12902-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-UVRAG/LRTOMT-12902-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-UVRAG/LRTOMT-12902-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-UVRAG/LRTOMT-12902-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-UVRAG/LRTOMT-12902-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-UVRAG/LRTOMT-12902-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-UVRAG/LRTOMT-12902-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-UVRAG/LRTOMT-12902-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-UVRAG/LRTOMT-12902-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-UVRAG/LRTOMT-12902-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-UVRAG/LRTOMT-12902-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-UVRAG/LRTOMT-12902-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-UVRAG/LRTOMT-12902-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-UVRAG/LRTOMT-12902-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-UVRAG/LRTOMT-12902-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-UVRAG/LRTOMT-12902-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-UVRAG/LRTOMT-12902-AQAQ 467nm;467nm 418nm;418nm

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