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TBC1D5-HTT Gene Fusion FISH Probe

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Catalog: GFFP-TBC1D5/HTT-11741
Classification: Gene Fusion FISH Probes
Description: The TBC1D5-HTT Gene Fusion FISH Probecan detect the fusion of TBC1D5 and HTT genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: TBC1D5-HTT Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Huntingtin
Gene Summary 1 Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016]
Chromosome 1 Chromosome 4
Locus 1 4p16.3
Coordinates 1 This gene maps to 3076407-3245687 in GRCh37 coordinates.
Gene Name 2 TBC1 Domain Family Member 5
Gene Summary 2 The TBC1 Domain Family Member 5 (TBC1D5) gene is located on chr3 :17198653-17784240 at 3p24.3.
Chromosome 2 Chromosome3
Locus 2 3p24.3
Coordinates 2 This gene maps to 17198653-17784240 in GRCh37 coordinates.
Associated Diseases Kidney Renal Clear Cell Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-TBC1D5/HTT-11741-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-TBC1D5/HTT-11741-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-TBC1D5/HTT-11741-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-TBC1D5/HTT-11741-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-TBC1D5/HTT-11741-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-TBC1D5/HTT-11741-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-TBC1D5/HTT-11741-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-TBC1D5/HTT-11741-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-TBC1D5/HTT-11741-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-TBC1D5/HTT-11741-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-TBC1D5/HTT-11741-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-TBC1D5/HTT-11741-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-TBC1D5/HTT-11741-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-TBC1D5/HTT-11741-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-TBC1D5/HTT-11741-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-TBC1D5/HTT-11741-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-TBC1D5/HTT-11741-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-TBC1D5/HTT-11741-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-TBC1D5/HTT-11741-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-TBC1D5/HTT-11741-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-TBC1D5/HTT-11741-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-TBC1D5/HTT-11741-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-TBC1D5/HTT-11741-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-TBC1D5/HTT-11741-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-TBC1D5/HTT-11741-AQAQ 467nm;467nm 418nm;418nm

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