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SMAD4-SKAP1 Gene Fusion FISH Probe

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Catalog: GFFP-SMAD4/SKAP1-11172
Classification: Gene Fusion FISH Probes
Description: The SMAD4-SKAP1 Gene Fusion FISH Probecan detect the fusion of SMAD4 and SKAP1 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: SMAD4-SKAP1 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 SMAD Family Member 4
Gene Summary 1 This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
Chromosome 1 Chromosome 18
Locus 1 18q21.2
Coordinates 1 This gene maps to 48556582-48611411 in GRCh37 coordinates.
Gene Name 2 Src Kinase Associated Phosphoprotein 1
Gene Summary 2 This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Chromosome 2 Chromosome17
Locus 2 17q21.32
Coordinates 2 This gene maps to 46210801-46507594 in GRCh37 coordinates.
Associated Diseases Prostate Adenocarcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-SMAD4/SKAP1-11172-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-SMAD4/SKAP1-11172-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-SMAD4/SKAP1-11172-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-SMAD4/SKAP1-11172-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-SMAD4/SKAP1-11172-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-SMAD4/SKAP1-11172-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-SMAD4/SKAP1-11172-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-SMAD4/SKAP1-11172-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-SMAD4/SKAP1-11172-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-SMAD4/SKAP1-11172-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-SMAD4/SKAP1-11172-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-SMAD4/SKAP1-11172-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-SMAD4/SKAP1-11172-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-SMAD4/SKAP1-11172-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-SMAD4/SKAP1-11172-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-SMAD4/SKAP1-11172-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-SMAD4/SKAP1-11172-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-SMAD4/SKAP1-11172-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-SMAD4/SKAP1-11172-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-SMAD4/SKAP1-11172-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-SMAD4/SKAP1-11172-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-SMAD4/SKAP1-11172-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-SMAD4/SKAP1-11172-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-SMAD4/SKAP1-11172-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-SMAD4/SKAP1-11172-AQAQ 467nm;467nm 418nm;418nm

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