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PPM1D-NUP85 Gene Fusion FISH Probe

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Catalog: GFFP-PPM1D/NUP85-09333
Classification: Gene Fusion FISH Probes
Description: The PPM1D-NUP85 Gene Fusion FISH Probecan detect the fusion of PPM1D and NUP85 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: PPM1D-NUP85 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Protein Phosphatase, Mg2+/Mn2+ Dependent 1D
Gene Summary 1 The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Chromosome 1 Chromosome 17
Locus 1 17q23.2
Coordinates 1 This gene maps to 58677543-58743640 in GRCh37 coordinates.
Gene Name 2 Nucleoporin 85
Gene Summary 2 This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome 2 Chromosome17
Locus 2 17q25.1
Coordinates 2 This gene maps to 73201596-73231854 in GRCh37 coordinates.
Associated Diseases Brain Lower Grade Glioma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-PPM1D/NUP85-09333-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-PPM1D/NUP85-09333-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-PPM1D/NUP85-09333-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-PPM1D/NUP85-09333-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-PPM1D/NUP85-09333-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-PPM1D/NUP85-09333-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-PPM1D/NUP85-09333-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-PPM1D/NUP85-09333-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-PPM1D/NUP85-09333-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-PPM1D/NUP85-09333-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-PPM1D/NUP85-09333-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-PPM1D/NUP85-09333-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-PPM1D/NUP85-09333-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-PPM1D/NUP85-09333-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-PPM1D/NUP85-09333-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-PPM1D/NUP85-09333-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-PPM1D/NUP85-09333-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-PPM1D/NUP85-09333-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-PPM1D/NUP85-09333-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-PPM1D/NUP85-09333-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-PPM1D/NUP85-09333-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-PPM1D/NUP85-09333-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-PPM1D/NUP85-09333-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-PPM1D/NUP85-09333-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-PPM1D/NUP85-09333-AQAQ 467nm;467nm 418nm;418nm

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