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- LAMC2-NMNAT2 Gene Fusion FISH Probe
Catalog: | GFFP-LAMC2/NMNAT2-06402 |
Classification: | Gene Fusion FISH Probes |
Description: | The LAMC2-NMNAT2 Gene Fusion FISH Probecan detect the fusion of LAMC2 and NMNAT2 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Category: | Gene Fusion FISH Probes |
Application: | LAMC2-NMNAT2 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality. |
Probe Kits Volume (µL): | 40 μL |
Quantity: | 20 Tests |
Hybridization Solution (µL): | 200 μL |
Turnaround Time: | 7-10 Business Days |
Shipping Time: | 1-2 Day Expedited Shipping |
Storage Conditions: | Store at -20℃ and avoid light; |
Shipping Conditions: | -20℃ |
Gene Name 1 | Laminin Subunit Gamma 2 |
Gene Summary 1 | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011] |
Chromosome 1 | Chromosome 1 |
Locus 1 | 1q25.3 |
Coordinates 1 | This gene maps to 183155173-183214262 in GRCh37 coordinates. |
Gene Name 2 | Nicotinamide Nucleotide Adenylyltransferase 2 |
Gene Summary 2 | This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Chromosome 2 | Chromosome1 |
Locus 2 | 1q25.3 |
Coordinates 2 | This gene maps to 183217371-183387634 in GRCh37 coordinates. |
Associated Diseases | Uterine Corpus Endometrial Carcinoma |
Species | Human |
Number | Dye Color | Order Name | Absorbance Maximum | Emission Maximum | Add to Cart |
1 | RE; RE | GFFP-LAMC2/NMNAT2-06402-RERE | 599nm;599nm | 580nm;580nm | |
2 | RE; OR | GFFP-LAMC2/NMNAT2-06402-REOR | 599nm;573nm | 580nm;548nm | |
3 | RE; GO | GFFP-LAMC2/NMNAT2-06402-REGO | 599nm;551nm | 580nm;525nm | |
4 | RE; GR | GFFP-LAMC2/NMNAT2-06402-REGR | 599nm;515nm | 580nm;491nm | |
5 | RE; AQ | GFFP-LAMC2/NMNAT2-06402-REAQ | 599nm;467nm | 580nm;418nm | |
6 | OR; RE | GFFP-LAMC2/NMNAT2-06402-ORRE | 573nm;599nm | 548nm;580nm | |
7 | OR; OR | GFFP-LAMC2/NMNAT2-06402-OROR | 573nm;573nm | 548nm;548nm | |
8 | OR; GO | GFFP-LAMC2/NMNAT2-06402-ORGO | 573nm;551nm | 548nm;525nm | |
9 | OR; GR | GFFP-LAMC2/NMNAT2-06402-ORGR | 573nm;515nm | 548nm;491nm | |
10 | OR; AQ | GFFP-LAMC2/NMNAT2-06402-ORAQ | 573nm;467nm | 548nm;418nm | |
11 | GO; RE | GFFP-LAMC2/NMNAT2-06402-GORE | 551nm;599nm | 525nm;580nm | |
12 | GO; OR | GFFP-LAMC2/NMNAT2-06402-GOOR | 551nm;573nm | 525nm;548nm | |
13 | GO; GO | GFFP-LAMC2/NMNAT2-06402-GOGO | 551nm;551nm | 525nm;525nm | |
14 | GO; GR | GFFP-LAMC2/NMNAT2-06402-GOGR | 551nm;515nm | 525nm;491nm | |
15 | GO; AQ | GFFP-LAMC2/NMNAT2-06402-GOAQ | 551nm;467nm | 525nm;418nm | |
16 | GR; RE | GFFP-LAMC2/NMNAT2-06402-GRRE | 515nm;599nm | 491nm;580nm | |
17 | GR; OR | GFFP-LAMC2/NMNAT2-06402-GROR | 515nm;573nm | 491nm;548nm | |
18 | GR; GO | GFFP-LAMC2/NMNAT2-06402-GRGO | 515nm;551nm | 491nm;525nm | |
19 | GR; GR | GFFP-LAMC2/NMNAT2-06402-GRGR | 515nm;515nm | 491nm;491nm | |
20 | GR; AQ | GFFP-LAMC2/NMNAT2-06402-GRAQ | 515nm;467nm | 491nm;418nm | |
21 | AQ; RE | GFFP-LAMC2/NMNAT2-06402-AQRE | 467nm;599nm | 418nm;580nm | |
22 | AQ; OR | GFFP-LAMC2/NMNAT2-06402-AQOR | 467nm;573nm | 418nm;548nm | |
23 | AQ; GO | GFFP-LAMC2/NMNAT2-06402-AQGO | 467nm;551nm | 418nm;525nm | |
24 | AQ; GR | GFFP-LAMC2/NMNAT2-06402-AQGR | 467nm;515nm | 418nm;491nm | |
25 | AQ; AQ | GFFP-LAMC2/NMNAT2-06402-AQAQ | 467nm;467nm | 418nm;418nm |
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