Gene-specific Copy Number Variation Probe-VEGFA
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| Catalog: |
CNVFP-VEGFA-22883 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (VEGFA). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
VEGFA Gene-specific copy number variation probes are mainly used to detect the copy number variation related to VEGFA genes. This product achieves the purpose of detection by hybridizing with the VEGFA gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Vascular Endothelial Growth Factor A |
| Gene Summary [Provided by RefSeq] |
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015] |
| Gene Symbol |
VEGFA |
| Location |
6p21.1 |
| Chromosome |
Chromosome6 |
| Coordinates |
This gene maps to 43737945-43754223 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-VEGFA-22883-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-VEGFA-22883-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-VEGFA-22883-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-VEGFA-22883-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-VEGFA-22883-AQ |
467nm |
418nm |
|
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