Gene-specific Copy Number Variation Probe-PREX2
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| Catalog: |
CNVFP-PREX2-16360 |
| Classification: |
Copy Number Variation |
| Description: |
Our Gene-specific Copy Number Variation Probes usually target the flanks of the target gene (PREX2). The product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We provide CNV FISH Probes with a variety of dye color combinations to meet various challenges. Probe products not only provide some classic color combinations but also provide customized probe services. |
| Application: |
PREX2 Gene-specific copy number variation probes are mainly used to detect the copy number variation related to PREX2 genes. This product achieves the purpose of detection by hybridizing with the PREX2 gene. Due to this design method, our probe products can detect the amplification and deletion of target genes on chromosomes through FISH. |
| Category: |
Copy Number Variation |
| Probe Kits Volume (µL): |
40 μL |
| Quantity: |
20 Tests |
| Hybridization Solution (µL): |
200 μL |
| Turnaround Time: |
7-10 Business Days |
| Shipping Time: |
1-2 Day Expedited Shipping |
| Storage Conditions: |
Store at -20℃ and avoid light; |
| Shipping Conditions: |
-20℃ |
Gene Details
| Gene Name |
Phosphatidylinositol-3,4,5-trisphosphate Dependent Rac Exchange Factor 2 |
| Gene Summary [Provided by RefSeq] |
The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016] |
| Gene Symbol |
PREX2 |
| Location |
8q13.2 |
| Chromosome |
Chromosome8 |
| Coordinates |
This gene maps to 68864602-69143897 in GRCh37 coordinates. |
| Species |
Human |
Dye Colors:
OR
RE
GO
GR
AQ
Order Sheet
| Number |
Dye Color |
Order Name |
Absorbance Maximum |
Emission Maximum |
Add to Cart |
| 1 |
OR
|
CNVFP-PREX2-16360-OR |
573nm |
548nm |
|
| 2 |
RE
|
CNVFP-PREX2-16360-RE |
599nm |
580nm |
|
| 3 |
GO
|
CNVFP-PREX2-16360-GO |
551nm |
525nm |
|
| 4 |
GR
|
CNVFP-PREX2-16360-GR |
515nm |
491nm |
|
| 5 |
AQ
|
CNVFP-PREX2-16360-AQ |
467nm |
418nm |
|
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