FAM110B-PREX2 Gene Fusion FISH Probe

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Catalog:	GFFP-FAM110B/PREX2-04120
Classification:	Gene Fusion FISH Probes
Description:	The FAM110B-PREX2 Gene Fusion FISH Probecan detect the fusion of FAM110B and PREX2 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Application:	FAM110B-PREX2 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Quantity:	20 Tests
Probe Kits Volume (µL):	40 μL
Hybridization Solution (µL):	200 μL
Turnaround Time:	7-10 Business Days
Shipping Time:	1-2 Day Expedited Shipping
Shipping Conditions:	-20℃
Storage Conditions:	Store at -20℃ and avoid light;

Gene Details

Gene Name 1	Phosphatidylinositol-3,4,5-trisphosphate Dependent Rac Exchange Factor 2
Gene Summary 1	The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]
Chromosome 1	Chromosome 8
Locus 1	8q13.2
Coordinates 1	This gene maps to 68864602-69143897 in GRCh37 coordinates.
Gene Name 2	Family With Sequence Similarity 110 Member B
Chromosome 2	Chromosome8
Locus 2	8q12.1
Coordinates 2	This gene maps to 58907112-59062277 in GRCh37 coordinates.
Associated Diseases	Prostate Adenocarcinoma
Species	Human

Dye Colors:

RE RE RE OR RE GO RE GR RE AQ OR RE OR OR OR GO OR GR OR AQ GO RE GO OR GO GO GO GR GO AQ GR RE GR OR GR GO GR GR GR AQ AQ RE AQ OR AQ GO AQ GR AQ AQ

Order Sheet

Number	Dye Color	Order Name	Absorbance Maximum	Emission Maximum	Add to Cart
1	RE; RE	GFFP-FAM110B/PREX2-04120-RERE	599nm;599nm	580nm;580nm
2	RE; OR	GFFP-FAM110B/PREX2-04120-REOR	599nm;573nm	580nm;548nm
3	RE; GO	GFFP-FAM110B/PREX2-04120-REGO	599nm;551nm	580nm;525nm
4	RE; GR	GFFP-FAM110B/PREX2-04120-REGR	599nm;515nm	580nm;491nm
5	RE; AQ	GFFP-FAM110B/PREX2-04120-REAQ	599nm;467nm	580nm;418nm
6	OR; RE	GFFP-FAM110B/PREX2-04120-ORRE	573nm;599nm	548nm;580nm
7	OR; OR	GFFP-FAM110B/PREX2-04120-OROR	573nm;573nm	548nm;548nm
8	OR; GO	GFFP-FAM110B/PREX2-04120-ORGO	573nm;551nm	548nm;525nm
9	OR; GR	GFFP-FAM110B/PREX2-04120-ORGR	573nm;515nm	548nm;491nm
10	OR; AQ	GFFP-FAM110B/PREX2-04120-ORAQ	573nm;467nm	548nm;418nm
11	GO; RE	GFFP-FAM110B/PREX2-04120-GORE	551nm;599nm	525nm;580nm
12	GO; OR	GFFP-FAM110B/PREX2-04120-GOOR	551nm;573nm	525nm;548nm
13	GO; GO	GFFP-FAM110B/PREX2-04120-GOGO	551nm;551nm	525nm;525nm
14	GO; GR	GFFP-FAM110B/PREX2-04120-GOGR	551nm;515nm	525nm;491nm
15	GO; AQ	GFFP-FAM110B/PREX2-04120-GOAQ	551nm;467nm	525nm;418nm
16	GR; RE	GFFP-FAM110B/PREX2-04120-GRRE	515nm;599nm	491nm;580nm
17	GR; OR	GFFP-FAM110B/PREX2-04120-GROR	515nm;573nm	491nm;548nm
18	GR; GO	GFFP-FAM110B/PREX2-04120-GRGO	515nm;551nm	491nm;525nm
19	GR; GR	GFFP-FAM110B/PREX2-04120-GRGR	515nm;515nm	491nm;491nm
20	GR; AQ	GFFP-FAM110B/PREX2-04120-GRAQ	515nm;467nm	491nm;418nm
21	AQ; RE	GFFP-FAM110B/PREX2-04120-AQRE	467nm;599nm	418nm;580nm
22	AQ; OR	GFFP-FAM110B/PREX2-04120-AQOR	467nm;573nm	418nm;548nm
23	AQ; GO	GFFP-FAM110B/PREX2-04120-AQGO	467nm;551nm	418nm;525nm
24	AQ; GR	GFFP-FAM110B/PREX2-04120-AQGR	467nm;515nm	418nm;491nm
25	AQ; AQ	GFFP-FAM110B/PREX2-04120-AQAQ	467nm;467nm	418nm;418nm

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