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AHI1-CHEK2 Gene Fusion FISH Probe

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Catalog: GFFP-AHI1/CHEK2-00291
Classification: Gene Fusion FISH Probes
Description: The AHI1-CHEK2 Gene Fusion FISH Probecan detect the fusion of AHI1 and CHEK2 genes. Our product usually consists of a combination of reagents, which consists of a probe with a selected dye color and a hybridization reagent. We offer a variety of dye color combinations for FISH probes for gene fusions. This product has been verified in both interphase nuclei and metaphase spreads of normal peripheral blood. This is key quality control, you can trust our quality.
Category: Gene Fusion FISH Probes
Application: AHI1-CHEK2 Gene Fusion FISH Probe can be used for chromosomal diagnosis to determine gene fusion phenomena associated with diseases such as cancer. You can confirm this in "Associated Diseases" in the product information. This product has been verified in both interphase nuclei and metaphase spreads ​of normal peripheral blood. This is key quality control, you can trust our quality.
Probe Kits Volume (µL): 40 μL
Quantity: 20 Tests
Hybridization Solution (µL): 200 μL
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping
Storage Conditions: Store at -20℃ and avoid light;
Shipping Conditions: -20℃

Gene Details

Gene Name 1 Checkpoint Kinase 2
Gene Summary 1 In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome 1 Chromosome 22
Locus 1 22q12.1
Coordinates 1 This gene maps to 29083730-29137822 in GRCh37 coordinates.
Gene Name 2 Abelson Helper Integration Site 1
Gene Summary 2 This gene is apparently required for both cerebellar and cortical development in humans. This gene mutations cause specific forms of Joubert syndrome-related disorders. Joubert syndrome (JS) is a recessively inherited developmental brain disorder with several identified causative chromosomal loci. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Chromosome 2 Chromosome6
Locus 2 6q23.3
Coordinates 2 This gene maps to 135605109-135818903 in GRCh37 coordinates.
Associated Diseases Breast Invasive Carcinoma
Species Human

Order Sheet

Number Dye Color Order Name Absorbance Maximum Emission Maximum Add to Cart
1 RE; RE GFFP-AHI1/CHEK2-00291-RERE 599nm;599nm 580nm;580nm
2 RE; OR GFFP-AHI1/CHEK2-00291-REOR 599nm;573nm 580nm;548nm
3 RE; GO GFFP-AHI1/CHEK2-00291-REGO 599nm;551nm 580nm;525nm
4 RE; GR GFFP-AHI1/CHEK2-00291-REGR 599nm;515nm 580nm;491nm
5 RE; AQ GFFP-AHI1/CHEK2-00291-REAQ 599nm;467nm 580nm;418nm
6 OR; RE GFFP-AHI1/CHEK2-00291-ORRE 573nm;599nm 548nm;580nm
7 OR; OR GFFP-AHI1/CHEK2-00291-OROR 573nm;573nm 548nm;548nm
8 OR; GO GFFP-AHI1/CHEK2-00291-ORGO 573nm;551nm 548nm;525nm
9 OR; GR GFFP-AHI1/CHEK2-00291-ORGR 573nm;515nm 548nm;491nm
10 OR; AQ GFFP-AHI1/CHEK2-00291-ORAQ 573nm;467nm 548nm;418nm
11 GO; RE GFFP-AHI1/CHEK2-00291-GORE 551nm;599nm 525nm;580nm
12 GO; OR GFFP-AHI1/CHEK2-00291-GOOR 551nm;573nm 525nm;548nm
13 GO; GO GFFP-AHI1/CHEK2-00291-GOGO 551nm;551nm 525nm;525nm
14 GO; GR GFFP-AHI1/CHEK2-00291-GOGR 551nm;515nm 525nm;491nm
15 GO; AQ GFFP-AHI1/CHEK2-00291-GOAQ 551nm;467nm 525nm;418nm
16 GR; RE GFFP-AHI1/CHEK2-00291-GRRE 515nm;599nm 491nm;580nm
17 GR; OR GFFP-AHI1/CHEK2-00291-GROR 515nm;573nm 491nm;548nm
18 GR; GO GFFP-AHI1/CHEK2-00291-GRGO 515nm;551nm 491nm;525nm
19 GR; GR GFFP-AHI1/CHEK2-00291-GRGR 515nm;515nm 491nm;491nm
20 GR; AQ GFFP-AHI1/CHEK2-00291-GRAQ 515nm;467nm 491nm;418nm
21 AQ; RE GFFP-AHI1/CHEK2-00291-AQRE 467nm;599nm 418nm;580nm
22 AQ; OR GFFP-AHI1/CHEK2-00291-AQOR 467nm;573nm 418nm;548nm
23 AQ; GO GFFP-AHI1/CHEK2-00291-AQGO 467nm;551nm 418nm;525nm
24 AQ; GR GFFP-AHI1/CHEK2-00291-AQGR 467nm;515nm 418nm;491nm
25 AQ; AQ GFFP-AHI1/CHEK2-00291-AQAQ 467nm;467nm 418nm;418nm

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